Ten of the 16 sides also reached the same round two seasons ago and, as usual, the big five leagues dominate with 13 clubs hailing from either the English, Spanish, German, French and Italian leagues.
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European heavyweights Barcelona, Bayern Munich, Juventus and Paris St Germain all maintained their leads and Benfica toppled Sporting Lisbon.
All the latest football news from around Europe.
News of all that's transpired on and off the football field
Lionel Messi dragged Barcelona back from two goals down by scoring twice to snatch a 2-2 draw at home to Valencia in a thrilling encounter.
A weekend of surprise results across Europe's big leagues saw Bayern Munich's unbeaten run come to an end, Napoli knocked off top spot in Serie A and Manchester City toppled in the Premier League where Leicester City are the new leaders.
News of all that's transpired on and off the football field